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首页> 外文期刊>Frontiers in Computational Neuroscience >Numerical Study on Electrode Design for Rodent Deep Brain Stimulation With Implantations Cranial to Targeted Nuclei
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Numerical Study on Electrode Design for Rodent Deep Brain Stimulation With Implantations Cranial to Targeted Nuclei

机译:植入物血液刺激电极设计的数值研究颅脑对靶向核

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摘要

The globus pallidus internus and the subthalamic nucleus are common targets for deep brain stimulation to alleviate symptoms of Parkinson's disease and dystonia. In the rodent models, however, their direct targeting is hindered by the relatively large dimensions of applied electrodes. To reduce the neurological damage, the electrodes are usually implanted cranial to the nuclei, thus exposing the non-targeted brain regions to large electric fields and, in turn, possible undesired stimulation effects. In this numerical study, we analyze the spread of the fields for the conventional electrodes and several modifications. As a result, we present a relatively simple electrode design that allows an efficient focalization of the stimulating field in the inferiorly located nuclei.
机译:Globus pallidus Internus和亚粒细胞核是深脑刺激的常见目标,以缓解帕金森病和障碍的症状。然而,在啮齿动物模型中,它们的直接靶向由施加电极的相对大的尺寸阻碍。为了减少神经损伤,电极通常植入脑部颅脑,从而将非靶向脑区暴露于大电场,然后又可能是可能的不希望的刺激效果。在该数值研究中,我们分析了传统电极的场的扩散和几种修改。结果,我们提出了一种相对简单的电极设计,其允许在下位的核中有效地调节刺激场。

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