OBJECTIVE: The aim of the study is to compare the live birth rates between 1,500 I.U. of Human chorionic gonadotropin at the time of Gonadotropin-releasing hormone agonist trigger day or 35-36 h later on the oocyte pick-up day, without affecting the risk of significant ovarian hyperstimulation syndrome development in high-risk patients with peak E2 level 4,000 pg/mL STUDY DESIGN: This single-center prospective cohort study encompassed the period from March 2016 to March 2018 year. A total of 216 patients entered for final analysis, underwent a flexible antagonist protocol, intracytoplasmic sperm injection, and embryo transfer on the 3rd or 5th day in autologous cycles. Patients were randomized in one of two groups: Group A- Dual trigger group - 1,500 IU of Human chorionic gonadotropin at the time of Gonadotropin-releasing hormone agonist trigger day and Group B- 1,500 IU of Human chorionic gonadotropin 35-36 h later, on the oocyte pick-up day. To compare the two groups, we used nonparametric and parametric statistical tests. Significant differences were considered all values of p0.05. RESULTS: There is no significant difference between the two (A vs B) groups according to the average number of retrieved oocytes (13.08 vs 14.41 p=0.08), M II oocytes (10.5 vs 10.95 p=0.46), GV (1.24 vs 1.52 p=0.09, the fertility rate (68.46% vs 64.04% p=0.07). The dual trigger group (A) had a significantly higher live birth rate (62.29% vs 42.37% p0.05) compared with the Gonadotropin-releasing hormone-a trigger group (B). There were no cases of moderate or severe ovarian hyperstimulation syndrome in both groups. CONCLUSION: Our study shows that in hyper responders where the E2 peak is 4,000 pg/mL, the two approaches to the final oocyte maturation trigger have a correct outcome of the results, both in terms of the results from the in vitro fertilization and the low risk of ovarian hyperstimulation syndrome appearance.
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机译：目的：该研究的目的是比较1,500 I.u.之间的活产率。在促胆量释放激素激动剂触发日或35-36小时后的人绒毛膜促性腺激素在卵母细胞拾取日，不影响高危患者峰值E2水平的高风险患者的显着卵巢过度刺激综合征的风险<4,000 PG / ML研究设计：本单中心预期队列研究包括2016年3月至2018年3月的时间。总共进入最终分析的216名患者，经历了灵活的拮抗剂方案，氏菌精子注射，和在自体循环中的第3或第5天的胚胎转移。患者在两组中的一组中随机分配：组A-Dual Trigger组 - 1,500例人绒毛膜促性腺激素在促性腺激素 - 释放激素激动剂触发日和群B-1,500 IU人类绒毛膜促性腺激素35-36 H后来，卵母细胞拾取日。要比较两组，我们使用非参数和参数统计测试。认为显着差异是P <0.05的所有值。结果：两种（VS B）组之间没有显着差异，根据检索的卵母细胞的平均数量（13.08 vs14.41p = 0.08），M II卵ytes（10.5 Vs 10.95 p = 0.46），GV（1.24 Vs 1.52 P = 0.09，生育率（68.46％vs 64.04％p = 0.07）。与促性腺激素释放激素相比，双触发组（a）具有显着高的活率（62.29％与42.37％p <0.05）。触发组（B）。两组中没有中度或严重的卵巢过度刺激综合征。结论：我们的研究表明，在E2峰值<4,000 pg / ml的超应答者中，两种方法到最终卵母细胞成熟触发结果对结果的正确结果，无论是从体外施肥的结果和卵巢过度刺激综合征外观的低风险。
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