A 3 month old german shepered male puppy weight 10 kg was coming to pratap clinic of veterinary and veterinary medicine Manipuri Uttar Pradesh, for treatment. Earlier puppy was treated for tick infestation as per the owner told by given about 100 mg of ivermectin tablet orally. Owner observed some clinical sign after 8 to 10 medication. Clinical examination revealed hypothermia (101.2°F), tremors, ataxia, partial blindness, dilated pupil, weakness, incardination, no responsiveness, unable in defecation and behavioural changes. Therapeutic management was done by the administration of avil 1ml, neurokind 1.5 ml, RL 100 ml, NS 150ml, manitol 1-2ml/kg BW IV stat, vetacept 1ml/day, lasix 1.5ml repeated 10 hourly and dexamethasone @ 0.25-0.5mg/kg BW IM BID, rectal enema for passing feaces to withdrawal ivermectin on first day and with infusion of 150ml dextrose (5%) IV. The dog recovered uneventfully after treatment.
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