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A Review on Canine Leishmaniasis; Etiology, Clinical Sign, Pathogenesis, Treatment and Control Methods

机译:犬林曼病的综述;病因,临床符号,发病机制,治疗和控制方法

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摘要

Canine Leishmaniasis is a vector borne zoonotic disease caused by protozoan parasite belonging tothe genus Leishmania. It is basically a disease of animals that gets in to the human population when man, fliesand the animal reservoirs coexist in the same environment. The disease is transmitted to human and animals byblood sucking sand fly of the genus Lutzomyia in the new world and Phlebotomus in the old world. The primaryreservoir hosts of Leishmania species are sylvatic mammals such as forest rodents, hyraxes and wild canides.From domestic animals, dogs play an important role in the epidemiology of this disease. Leishmania species areflagellated and have two basic life cycle stages: the extracellular stage within the invertebrate host and theintracellular stage within vertebrate host. Clinically, imported dogs from endemic areas may develop the diseasemonths or years later. The disease is endemic in parts of Africa, India, Middle East, Southern Europe and centraland South America. Leishmaniasis can be diagnosed using various methods, such as: parasitological,immunological and molecular techniques. Different forms of treatments are available including oral parentral andtopical medications such as pentavalent antimonials, liposomal amphoteracin B, miltefosine and paromomycin.However, control methods are largely limited to: destruction of animal reservoirs, treatment of infected humanand animals and management of sand fly populations. Development of an effective vaccine againstleishmaniasis has been largely unsuccessful and hinders its prevention.
机译:犬利什曼病是一种由属于林德曼属的原生动物寄生虫引起的传染媒介。基本上基本上是一种动物疾病,当人类弗莱斯和动物储层在同一环境中共存时进入人口。该疾病被传播给血腥血淋淋的人类和动物的人和动物在新世界的新世界和痰多。 Leishmania物种的小学禽类是森林啮齿动物,患有林啮齿动物,乌龟和野生瓷器的杂种哺乳动物。从家畜中,狗在这种疾病的流行病学中发挥着重要作用。 LeishMania物种是斑块的,具有两个基本的生命周期阶段:无脊椎动物宿主和脊椎动物宿主中的细胞外阶段。临床上,流行地区的进口犬可能会在以后发展不安的宣传。该疾病是非洲,印度,中东,南欧和南美洲中心的部分地区。利什曼病可以使用各种方法进行诊断,例如:寄生虫学,免疫学和分子技术。可提供不同形式的治疗方法,包括口腔胃癌和戊类药物,如五价抗血清,脂质体Amphoteracin B,Miltefosine和Paromomycin。然而,控制方法主要限于:动物储层的破坏,感染的人和砂蝇种植的治疗。开发有效的疫苗抵抗持有的疫苗,在很大程度上不成功,阻碍了预防。

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