The ceRNA network of lncRNA and miRNA in lung cancer

摘要

Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies havebeen continuously conducted. Recently, long non-coding RNAs (lncRNAs) and microRNAs(miRNAs) are being exponentially studied as promising biomarkers of lung cancer. Moreover, supportive evidence provides the competing endogenous RNA (ceRNA) network between lncRNAs and miRNAs participating in lung tumorigenesis. This review introducedthe oncogenic or tumor-suppressive roles of lncRNAs and miRNAs in lung cancer cells andsummarized the involvement of the lncRNA/miRNA ceRNA networks in carcinogenesis andtherapeutic resistance of lung cancer.