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首页> 外文期刊>Genome Biology >Exploring neighborhoods in large metagenome assembly graphs using spacegraphcats reveals hidden sequence diversity
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Exploring neighborhoods in large metagenome assembly graphs using spacegraphcats reveals hidden sequence diversity

机译:使用太空图形探讨了探索大型MetageNome装配图中的社区显示隐藏的序列分集

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摘要

Genomes computationally inferred from large metagenomic data sets are often incomplete and may be missing functionally important content and strain variation. We introduce an information retrieval system for large metagenomic data sets that exploits the sparsity of DNA assembly graphs to efficiently extract subgraphs surrounding an inferred genome. We apply this system to recover missing content from genome bins and show that substantial genomic sequence variation is present in a real metagenome. Our software implementation is available at https://github.com/spacegraphcats/spacegraphcats under the 3-Clause BSD License.
机译:从大型偏见数据集推断出来的基因组通常不完整,并且可能缺失功能重要的内容和应变变化。我们介绍了一种用于大型偏见数据集的信息检索系统,该数据集利用DNA组装图的稀疏性以有效地提取推断基因组周围的子图。我们应用该系统以从基因组垃圾箱恢复缺失的内容,并表明实际的基因组序列变异存在于真正的梅塔群中。我们的软件实现可在3-Clase BSD许可证下在HTTPS://github.com/spachcats/spacegraphcats上获得。

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