Seroprevalence of Immunoglobulin M and GAntibodies against SARS-CoV-2 Virus: ASystematic Review and Meta-Analysis Study

摘要

Coronavirus disease 2019(COVID-19), caused bysevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), isa new global health threat.Objectives: to analyze the effectiveness of the measurement ofspecific antibodies to SARS-CoV2 (IgM and IgG) for the diagnosisof COVID-19 and to analyze the rate of SARS-CoV2 seroprevalencein the population.Methods: 11 relevant studies, published before June 5, 2020, wereincluded in this meta-analysis. These studies were identified bysearching the MEDLINE and Scopus databases. The final selectedstudies were analyzed using STATA version 14. Publication biaswas examined using both Egger’s test and Funnel plots. Moreover,the I2 statistic has been used to evaluate and verify heterogeneity.Results: The 11 relevant studies selected for the present metaanalysis cover a total of 996 infection cases. According to the results,the average rate of positive cases for IgM (AU/mL) was 2.10 (95%CI: 1.65-2.55; I2=92.2%), and the sensitivity in individuals withpositive IgM test was 63 (95% CI: 47-79; I2=94.9%). In addition,the average rate of positive cases for IgG (AU/mL) was 67.44 (95%CI: 28.79-106.09; I2=99.4%), and the sensitivity in individuals withpositive IgG test was 79 (95% CI: 67-90; I2=89.5%).Conclusions: According to this analysis, detection of anti-SARSCoV-2 IgM and IgG antibodies may assist early detection of SARSCoV2 infection. Whether antibodies against SARS-CoV-2 conferprotective immunity warrants further studies.