Beta- thalassemia (BT) is one of the most commonmonogenic disorders in the world whichinherited by an autosomal recessive manner.There are more than 1.5 million carriers of BT inthe world and almost 60000 new carriers are borneach year (1). BT is characterized by defect inbeta globin chain synthesis and imbalance of alpha/betaglobin portion causes sediment of extrachains and pathophysiologic changes in patients(2). BT is more prevalent in Mediterranean countries,Middle East, India, North Africa, centraland southwest Asia (3). The Allele frequency andmutation dispersion of BT are specific in eachpopulation. It often includes 4-5 common mutationsthat affect 90% of all cases. There are numerousrare mutations in each population (4).
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