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首页> 外文期刊>International Journal of Nanomedicine >The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review
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The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review

机译:碳纳米管在肺癌诊断和治疗中的应用:临界评论

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摘要

The importance of timely diagnosis and the complete treatment of lung cancer for many people with this deadly disease daily increases due to its high mortality. Diagnosis and treatment with helping the nanoparticles are useful, although they have reasonable harms. This article points out that the side effects of using carbon nanotube (CNT) in this disease treatment process such as inflammation, fibrosis, and carcinogenesis are very problematic. Toxicity can reduce to some extent using the techniques such as functionalizing to proper dimensions as a longer length, more width, and greater curvature. The targeted CNT sensors can be connected to various modified vapors. In this regard, with helping this method, screening makes non-invasive diagnosis possible. Researchers have also found that nanoparticles such as CNTs could be used as carriers to direct drug delivery, especially with chemotherapy drugs. Most of these carriers were multi-wall carbon nanotubes (MWCNT) used for cancerous cell targeting. The results of laboratory and animal researches in the field of diagnosis and treatment became very desirable and hopeful. The collection of researches summarized has highlighted the requirement for a detailed assessment which includes CNT dose, duration, method of induction, etc., to achieve the most controlled conditions for animal and human studies. In the discussion section, 4 contradictory issues are discussed which are invited researchers to do more research to get clearer results.
机译:及时诊断和完全治疗肺癌的许多人对许多致命疾病的完全治疗,每天增加死亡率。诊断和治疗有助于纳米颗粒是有用的,尽管它们具有合理的危害。本文指出,使用碳纳米管(CNT)在该疾病治疗方法如炎症,纤维化和致癌内发生的副作用非常有问题。毒性可以在一定程度上使用诸如官能化的技术,例如较长长度,更多宽度和更大的曲率。目标CNT传感器可以连接到各种改性蒸汽。在这方面,通过帮助这种方法,筛选使得不侵入性诊断成为可能。研究人员还发现,诸如CNT的纳米颗粒可以用作直接药物递送的载体,尤其是化疗药物。这些载体中的大多数是用于癌细胞靶向的多壁碳纳米管(MWCNT)。诊断和治疗领域的实验室和动物研究结果变得非常希望和充满希望。研究总结已经突出了详细评估的要求,该评估包括CNT剂量,持续时间,诱导方法等,以实现动物和人类研究的最受控制的条件。在讨论部分中,讨论了4个矛盾问题,邀请研究人员进行更多研究以获得更清晰的结果。

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