首页> 外文期刊>International Journal of Pharmacology and Toxicology >Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice
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Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice

机译:小鼠萨巴塞内加尔斯氏菌(Apocynaceae)叶片水提取物的潜在抗糖尿病性能

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This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p 0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.
机译:本研究使证明SABA Senegalensis在小鼠中具有降血糖和抗高血糖作用。 SABA Senegalensis的水提取物从75-250mg / kg BW导致剂量依赖性低血糖,从4.84〜34.62%(P <0.01-0.05),在治疗后60分钟。口服葡萄糖诱导的高血糖(OPGH)试验表明,在SABA Senegalensis含水提取物在75-250mg / kg Bw的浓度存在下,葡萄糖诱导的高血糖峰(3g / kg bw)从26.49降至71.77% (P <0.01-0.05),治疗后30分钟。口服该植物的水提取物的剂量可达5000mg / kg Bw,在两周的观察期间导致小鼠没有死亡。

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