Carvedilol is a non-selective beta- blocker with alpha-1-receptor blocking activity. Carvedilol drug is widely used in treatment of cardiovascular disease. Carvedilol is belonging to BCS Class II drug, It characterized by poor water solubility and high permeability. The main objective of this study is to enhance the solubility and dissolution rate of Carvedilol drug to achieve desired concentration of drug in systemic circulation for achieving the required pharmacological response by using Novel technique i.e., fluidized bed granulation technique by using wide variety of carriers such as PVP K30, Poloxamer 188 as a super disintegrant. The formulation F6 showed Enhance Solubility and Dissolution rate of Carvedilol drug released approximately 95.18% for 30min. So, it was selected as the best formulation among all the nine formulations.
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