A Case Control Study on Evaluating the Antihyperglycemic Effect of Hydroxychloroquine along with other Oral Hypoglycemic agent among Type II Diabetes Mellitus Patient in Major Trauma Care Centre

摘要

Hydroxychloroquine (HCQ) is an antimalarial and anti-inflammation drug recently approved in India for use in Diabetes.It acts by inhibiting the degradation of insulin and cause accumulation of insulin.In vitro studies have shown that it preserves islets cells and reduce inflammatory mediators.Treatment with higher dose of HCQ in obese subjects have shown improvement of insulin sensitivity and beta cell function.Acute trauma causes stress and inflammation and stress can cause new onset hyperglycemia and worsening of underlying diabetes mellitus.No study has used HCQ in post trauma setting.Current study has explored the use of HCQ in post trauma setting.The study is to evaluate the antihyperglycemic effect of Hydroxychloroquine along with other hypoglycemic agents among Type II Diabetes mellitus patient in major trauma care center.The objective of the present study was to evaluate the antihyperglycemic effect of the Hydroxychlo0roquine in Type II Diabetes mellitus patient and its adverse effects.It is prospective, interventional clinical study done in a major trauma care center.A total of 100 patient were included in the study.Hydroxychloroquine was introduced during hospital stay follow up was done after 3 and 6 months.Glycemic control was assessed by HbA1C and side effects were recorded.Out of 200 patients 62 completed the study at this time and 62 patients were included as control.The outcome is that mean baseline HbA1C from 10.68% was reduced to 7.25% in case and from 10.22% was reduced to 9.45% in control group.This shows that HCQ reduces 3.43% of HbA1c at first review in case whereas in control 0.77% of HbA1c was reduced.This study concludes that hydroxychloroquine can be an effective add on therapy to the subjects with uncontrolled Type II Diabetes Mellitus along with other Oral Hypoglycemic agents.