Floating drug delivery systems are promising systems that float immediately upon contact with gastric fluids which may increases the bioavailability of encapsulated drugs along with absorption in the intestine. The physiological and formulation variables affect the gastric retention towards the successful development of floating drug delivery formulations. Floating drug delivery formulation designs include single-unit and multiple-unit floating systems. Gastric emptying rate prolong and control the emptying time residing the stomach which supports the prolonged drug release. The mechanism by which gastro retentive systems works include upon contact with gastric fluids this system prolongs the residence time thereby improves bioavailability/solubility at the elevated pH condition and maximizes the drug at the target site. Here in the proposed review will provide insights towards the different gastroretentive drug delivery systems, polymers both natural and synthetic and applications of gastroretentive drug delivery systems. Special emphasis will be made towards the factors affecting gastro retentive drug delivery systems. Additionally, the process challenges and future perspectives towards the commercialization of gastroretentive drug delivery systems will be also discussed.
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