The work descibe a modified screen printed electrode (SPE) for the concurrent analysis of gliclazideand glibenclamide. The modification of the SPE was performed using Fe3O4nanoparticles (Fe3O4NPs)derivative. When used for the oxidation of gliclazide under optimal conditions, the over-potentialassociated with the oxidation of gliclazide dropped for about 130 mV as opposed to the case ofunmodified SPEs. The modified electrodes were used to monitor the electrochemical-behavior ofgliclazide through differential pulse voltammetry (DPV) and cyclic voltammetry (CV), and also obtainsome kinetic data on gliclazide. The response of the electrode was found to be linear from 0.5 to 600.0μM and a detection limit of 0.1 μM (based on 3s/m) was reached through DPV. The Fe3O4 NP/SPEwas applied to the determine gliclazide and glibenclamide in the drug and urine samples. The resultsindicated satisfactory recovery of two analytes. Hence, it was concluded that the electrode is applicablefor the analysis of gliclazide and glibenclamide in drug administration and clinical laboratories.
展开▼
