Herein, the impact of electroactivation of glassy carbon electrode on the paracetamol drugelectrochemical behavior is investigated for the first time. The morphology of the GC electrode surfacewas investigated using SEM. The extent of oxidation of GC as well as the pH of the supportingelectrolyte has been investigated. The oxidation of GC results in the formation of several containingoxygen functional groups which increases with increasing the number of potential cycles for oxidation.The extent of GC oxidation was quantified by calculating the number of surface’s quinone units (S), ascalculated from the voltammetric measurements in 1.0 M H2SO4. Then the S was correlated with theextent of electrocatalytic oxidation of PC. Based on the voltammetric studies, it has been found that theoxidation of PC is controlled by both diffusion and adsorption processes. Finally, the activation of GCelectrode was used for the quantitative determination of PC in a suitable rectilinear range with a standarddevation and relataive standard deviation (RSD) of 0.17 mM and 2.4%, respictively..
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