Abstract Participant-reported outcomes are important. Prior MOVE UP reports show ≥5% weight loss was not significantly associated with depressive symptoms but was associated with positive SPPB physical function and the Physical Component Score of the SF-36 HRQOL scale. We examined the SF-36 subscales that showed, a priori, clinically meaningful 5.0-point increases over 13 months, the change in subscales per 5% weight loss, and variability by race. Among all participants (n =240) several subscales show significant pre-post changes [mean (SD)] but only Vitality [ 5.6 (15.4)] and Physical Function [ 5.0 (16.7)] meet the criterion. Blacks (n = 60) compared to Whites (n = 172) had higher baseline scores on these subscales, were less likely to lose ≥5% (31.7% vs. 59.9%), but mixed regression models indicate that those who did demonstrated a larger change on Vitality ( 5.2; p0.048) than Whites ( 3.1; p0.0003). Studying weight loss and HRQOL associations in larger minority samples is needed.
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机译：摘要报告的结果是重要的。之前的上升报告显示≥5％的体重减轻与抑郁症状没有显着相关，但与SPP物理功能和SF-36 HRQOL规模的物理成分分数有关。我们检查了SF-36分量表明，先验，临床有意义的5.0点超过13个月增加，每5％减重的分量的变化，以及比赛的变异性。在所有参与者（n = 240）中，若干分量显示出显着的前后变化[均值（SD）]，但仅活力[5.6（15.4）]和物理功能[5.0（16.7）]符合标准。与白人（n = 60）相比，与白人（n = 172）相比这些分量器上的基线评分更高，不太可能损失≥5％（31.7％与59.9％），但混合回归模型表明那些确实证明了一个人的人更大的变化活力（5.2; p <0.048）比白人（3.1; p <0.0003）。需要研究体重减轻和少数群体样本中的HRQOL关联。
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