To study the clinical features of HPV58-positive cervical cancer. A retrospective analysis of 347 patients with HPV58- or HPV16 positive cervical cancer from the Department of Gynecology Tumor of Guangxi Medical University Affiliated Cancer Hospital was performed. Molecular hybridization was used to detect HPV genotypes. The clinical features, including age, pathology, and invasion, were compared between the HPV58 positive and HPV16 positive cervical cancer groups. A total of 347 patients were eligible for this study, and the proportion of patients who were with poorly differentiated cancer (P?=?0.015) was significantly higher in the HPV58 positive group. HPV58 positivity was an independent risk factor for poorly differentiated cancer [HR 2.156, 95% confidence interval: 1.167–3.984, P?=?0.014]. The percentage of uterus corps invasion is significantly lower in HPV58 (p?=?0.041), but HPV58 positivity is the independent risk factor for uterus corps invasion [HR?=?3.985, 95% confidence interval: 1.066–14.893, P?=?0.040]. The overall survival of HPV58-positive cervical cancer patients with uterine corpus invasion was significantly lower (P?=?0.000). The age of patients in the HPV58-positive cervical cancer at advanced stage was significantly older (P?=?0.045). HPV58-positive cervical cancer patients are at higher risk of poorly differentiated cancer and uterus corps invasion. The patients with HPV58 positive cervical cancer with uterus corps invasion may result a worse prognosis.
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