Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China

摘要

Background: RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported.Methods and Results: Three rmtF -positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla OXA-232 and bla CTX-M-15 . The rmtF gene was located on an IncFIB transformable plasmid of 128,536-bp and bla OXA-232 was on a 6141-bp ColKP3 plasmid, respectively. Conclusion: Plasmids with rmtF found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing rmtF and bla OXA-232 are gradually increasing in China.