Expression of Human Herpes Virus 6, 7, Epstein-Barr Virus and Cytomegalovirus in Patients with Diverse Adverse Cutaneous Reactions to Drug

摘要

Various drugs can cause diverse cutaneous adverse drug reactions (CADR)1 . Factors have been implicated in CADR, including the dosage, duration of use, physiological status and genetic background of the patient1 . In addition, current or past viral infection has been reported to affect the occurrence of CADR2 . In particular, many authors have suggested the activation of human herpes virus (HHV) 6, 7, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in patients with drug-induced hypersensitivity syndrome (DIHS)2,3. However, aside from DIHS, there are scarce data regarding the relationship of HHV 6, 7, EBV, and CMV with the overall CADR. Herein, we report viral expression in patients showing various types of CADR in real clinical situations.