Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high‐fat diet using the collaborative cross mouse model

摘要

Background Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes (T2D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically highly diverse inbred mouse lines, namely collaborative cross (CC), for dissecting host susceptibility for the development of T2D and obesity, showing significant variations following high‐fat (42% fat) diet (HFD). Here, we aimed to assessing the host genetic background and sex effects on T2D and obesity development in response to oral‐mixed bacterial infection and HFD using the CC lines.