Expanding luminal epitheliums as cells of origin for prostate cancer

摘要

Despite tremendous progress made in human prostate biology over the past few decades, a full picture of prostate lineage hierarchy and its connection to cancer initiation remaintobedelineated.TworecentstudiespublishedinNat Genet. [1] and in Science [2] have profiled subpopulations of prostate cells at the single-cell level. Complementary ana- lyses of data from the studies demonstrate self-renewal and differentiation capacities of different luminal epithelial cells, which can serve as cells of origin for prostate cancer.