Anti-Cancer Natural Products Inducing Cross-talk between Apoptosis and Autophagy Mutual Proteins to Regulate Cancer Cell Death: Design of Future Green Anticancer Therapies

摘要

The present letter concerns anti-cancer naturalproducts inducing cross-talk between apoptosis andautophagy mutual proteins to regulate cancer cell deathfor future cancer green therapeutic approaches. The courseof cancer advancement has always been attributed to thedefectiveness in cell death mechanisms (Du et al., 2013;Hematulin et al., 2014). These defects act as a shield inprotecting tumor cells from drugs and therapies, all at thesame time, maintaining a longer life span and promptingtheir dispersion procedures. Autophagy and apoptosissafeguards cells from cellular damages and maintainsproliferation and homeostasis by deporting outgrowthand controlling differentiation of pernicious cells. Theautophagic proteins are conventionally found in hinderingapoptosis whereas vice versa accounts had been reportedfor apoptotic-intermediates in preventing autophagicresponses.