Effect of Intraoperative Glucose Fluctuation and Postoperative IL-6, TNF-α, CRP Levels on the Short-term Prognosis of Patients with Intracranial Supratentorial Neoplasms

摘要

Objective: To investigate the effect of intraoperative glucose fluctuation and postoperative interlukin-6 (IL-6), tumor necrosis factor- (TNF- ), C-reactive protein (CRP) levels on the short-term prognosis of patients with intracranial supratentorial neoplasms. Materials and Methods: Eighty-six patients undergoing intracranial excision were selected in The Second Hospital of Jilin University. According to the condition of glucose fluctuation, the patients were divided into group A (glucose fluctuation , n=29). Glucose was assessed by drawing 2 mL blood from internal jugular vein in two groups in the following time points, namely fasting blood glucose 1 d before operation ( ), 5 min after anesthesia induction ( ), intraoperative peak glucose ( ), intraoperative lowest glucose ( ), 5 min after closing the skull ( ), immediately after returning to intensive care unit (ICU) ( ) and 2 h after returning to ICU ( ). 1 d before operation and 1, 3 and 6 d after operation, serum IL-6 and TNF- levels were detected with enzyme-linked immunosorbent assay (ELISA), and CRP level with immunoturbidimetry. Additionally, postoperative adverse reactions were monitored. Results: There was no statistical significance between two groups regarding the operation time, anesthesia time, amount of intraoperative bleeding and blood transfusion (P0.05). The glucose levels in both groups at went up conspicuously compared with that at (P , , and were significantly higher than in group A (P and CRP levels in both groups 1, 3 and 6 d after operation increased markedly compared with 1 d before operation (P and CRP levels and those with small range of glucose fluctuation have better prognosis.