Objective: To assess the diagnostic and prognostic value of AFP and des-gamma-carboxyprothrombin (DCP) in combination and alone for hepatocellular carcinoma. Materials and Methods: A case control study carried out in the Department of Biochemistry of Manipal College of Medical Sciences, Pokhara, Nepal between January 2010 and December 2011. The variables collected were age, gender, BMI, total proteins, albumin, AST, ALT, total bilirubin, DCP, AFP. Approval for the study was obtained from the institutional research ethical committee. Estimation of AFP was performed by ELISA reader for all cases. Analysis was done using descriptive statistics and confidence interval (CI). The data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results:The mean age of HCC cases was yrs. The percentage of females was less than males in both cases (23%) and controls (29%). The specificity of DCP reached 100% when its values was equal or greater than 150 (MAU/ml) for 0, 3, 6, 9, 12 months preceding the diagnosis of HCC. Similarly, the specificity for AFP was also nearly 100% when its value was equal or greater than 200 ng/ml 0, 3, 6, 9, 12 months earlier to the finding of HCC. The specificity of DCP ( ) and AFP( ng/mL) in combination was 93%, 97%, 95%, 96%, 97% in respect to 0, 3, 6, 9, 12 months prior to the diagnosis of HCC. Conclusion: The combination of both DCP and AFP will improve the finding of initial HCC and the sensitivity of these markers was utmost at the time of HCC identification and noticeably lesser at former time points.
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机译:目的:评估AFP和DES-γ-羧基丙蛋白(DCP)组合的诊断和预后值,单独用于肝细胞癌。材料与方法:2010年1月至2011年1月尼泊尔医学院生物化学系进行了案例控制研究。收集的变量是年龄,性别,BMI,总蛋白,白蛋白,AST,ALT ,总胆红素,DCP,AFP。从机构研究道德委员会获得了该研究的批准。 AFP的估算由ELISA读者进行所有情况。使用描述性统计和置信区间(CI)进行分析。使用Excel 2003,R 2.8.0统计包来分析数据,用于Windows版本16.0(SPSS Inc; Chicago,IL,USA)和EPI Info 3.5.1 Windows版本的社会科学(SPSS)。结果:HCC病例的平均年龄是YRS。两种病例(23%)和对照(29%)的女性百分比小于男性。当HCC诊断前12个月的0,3,6,9,12个月,当值等于或大于150(MAU / ml)时,DCP的特异性达到100%。类似地,当其值相等或大于200ng / ml 0,3,6,9,12个月之前,AFP的特异性也接近100%,同时发现HCC。 DCP()和AFP(Ng / ml)的特异性组合为93%,97%,95%,96%,在诊断HCC之前的0,3,6,9,12个月内,96%,97%。结论:DCP和AFP的组合将改善初始HCC的发现,并且这些标记的敏感性在HCC识别时最大限度,以前的时间点明显较小。
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