Aim: To assess the endoscopic and clinicopathological features of early-onset gastric cancer (EOGC) in Vietnamese,a population with intermediate risk of gastric cancer. Patients and methods: Consecutive patients diagnosed withgastric adenocarcinoma were prospectively recruited. The demographic, clinical data in each patient were collected.The location and macroscopic type of all gastric lesions suspected to be malignant were reported according to theJapanese classification. The histologic tumor type of gastric cancer (GC) was classified according to the Laurenclassification. Helicobacter pylori (H. pylori) infection were diagnosed by rapid urease test and urinary H. pyloriantibody test. The infection was diagnosed when at least one of the two tests was positive. Results: The rate of EOGC(i.e. ≤ 40 years of age) was 16.3% (23/141). The median age of patients with EOGC was 35 (range 28 – 40) years andthe male-to-female was 1:1.09. Compared to the older group (i.e. ≥ 50 years of age), the rates of positive family history,H. pylori infection and alarm features in the EOGC group were not significantly different (0.0% vs. 5.4%, p = 0.581;73.9% vs. 66.3%, p = 0.620; and 60.8% vs. 79.3%, p = 0.100; respectively). The EOGC group had significantly higherrate of tumor extending to entire stomach (21.7% vs. 3.4%, p = 0.003); but the rate of diffuse-type GC between the twogroups were not significantly different (87.0% vs. 71.7%, p = 0.181). Conclusions: Vietnamese patients with EOGC hadhigher rate of tumor extending to entire stomach compared to the older group. But the family history of GC, H. pyloriinfection and the pathological characteristics were not significantly different between the two groups. Environmentalfactors which play important roles in the development of EOGC in Vietnam should be investigated in future study.
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