Objective: We aimed to compare the cytomorphological diagnosis in serous effusion and quality of backgroundbetween modified liquid-based cytology (modified-LBC) and CytoRich Red (CRR) preservative. Methods: We usedan experimental study design: 110 fresh serous effusions were received from 50 cases negative for malignant effusionsand 60 cases positive for malignant effusions. All fresh serous effusions were processed using both the CRR solutionand the modified-LBC preparation. Blind sample slides were interpreted for cytomorphological diagnosis and thequality of background by 2 cytotechnologists. Result: All cases had the same diagnosis irrespective of the method.There was no statistically significant difference in the cytological diagnosis between the CRR and modified-LBCpreparations (p0.999). The quality of the background smear for the CRR preparation was clean (54%), moderate in42%, and poor in 4%. By comparison, the modified-LBC preparation was clean in 46%, moderate in 47%, and poor in7%. The difference between the quality of background smears between the two methods was not statistically significant(p= 0.527). Conclusion: There was no statistically significant difference in the diagnosis or quality of backgroundbetween CRR and modified-LBC preparations. The serous effusion specimen prepared by modified-LBC solution wasless expensive than CRR. The modified-LBC could be an alternative preparation when commercial preparations aretoo expensive.
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