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COVID-19 in children: analysis of the first pandemic peak in England

机译:Covid-19儿童:英格兰第一个大流行峰的分析

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Objectives To assess disease trends, testing practices, community surveillance, case-fatality and excess deaths in children as compared with adults during the first pandemic peak in England. Setting England. Participants Children with COVID-19 between January and May 2020. Main outcome measures Trends in confirmed COVID-19 cases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity rates in children compared with adults; community prevalence of SARS-CoV-2 in children with acute respiratory infection (ARI) compared with adults, case-fatality rate in children with confirmed COVID-19 and excess childhood deaths compared with the previous 5 years. Results Children represented 1.1% (1,408/129,704) of SARS-CoV-2 positive cases between 16 January 2020 and 3 May 2020. In total, 540 305 people were tested for SARS-COV-2 and 129,704 (24.0%) were positive. In children aged 16 years, 35,200 tests were performed and 1408 (4.0%) were positive for SARS-CoV-2, compared to 19.1%–34.9% adults. Childhood cases increased from mid-March and peaked on 11 April before declining. Among 2,961 individuals presenting with ARI in primary care, 351 were children and 10 (2.8%) were positive compared with 9.3%–45.5% in adults. Eight children died and four (case-fatality rate, 0.3%; 95% CI 0.07% to 0.7%) were due to COVID-19. We found no evidence of excess mortality in children. Conclusions Children accounted for a very small proportion of confirmed cases despite the large numbers of children tested. SARS-CoV-2 positivity was low even in children with ARI. Our findings provide further evidence against the role of children in infection and transmission of SARS-CoV-2.
机译:在英格兰第一个大流行峰期间,评估疾病趋势,检测实践,社区监测,病例死亡和儿童过度死亡的目标。设置英格兰。参与者在1月至5月20日之间的Covid-19。主要结果措施措施趋势在确认的Covid-19病例,儿童的严重急性呼吸综合征冠状病毒2(SARS-COV-2)与成年人相比的阳性率;与成年人相比,急性呼吸道感染儿童的SARS-COV-2中SARS-COV-2的患病率,患有确诊的Covid-19和儿童儿童的病情率与过去5年相比。结果儿童为2020年1月16日至5月3日之间的SARS-COV-2阳性案件的1.1%(1,408 / 129,704)。总共对SARS-COV-2和129,704(24.0%)进行了阳性的540人。在<16岁的儿童中,进行了3​​5,200个测试,1408(4.0%)对于SARS-COV-2阳性,而成年人为19.1%-34.9%。童年案例从3月中旬增加,并于4月11日在下降之前达到顶峰。在初级保健中呈现ARI的2,961名中,351名是儿童,10(2.8%)阳性,成人含有9.3%-45.5%。 8名儿童死亡,四个(病例率,0.3%; 95%CI 0.07%至0.7%)是Covid-19。我们没有发现儿童死亡过多的证据。结论儿童占确诊案件的一小部分确认案件,尽管有大量的儿童进行了测试。 SARS-COV-2阳性甚至在ARI的儿童中都很低。我们的调查结果提供了违反儿童感染和传播SARS-COV-2的作用的进一步证据。
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