Background: Liver diseases are still among themost important health problems worldwide. In order tomake successful treatment,an accurate diagnosis is necessary.Objectives: In the forthcoming study, the level of menin protein expression and its relationship with early diagnosis of HBV-relatedHCC were studied in the liver tissue of Iranian patients.Methods: The study consisted of 30 healthy control individuals (C) and 121 patients (40 patients with HBV only, 41 patients with HCConly, and 40 patients with HBV + HCC). The level of menin expression in the liver samples of all volunteers was evaluated by IHC andqRT-PCR.Results: Statistically, the level of menin expression was different between HBV-related HCC and HBV groups. There was a significantrelationship between labeling index and immunohistochemical and molecular expressions of menin.Conclusions: Results emphasized the significant relationship between menin expression and risk of HCC in patients with HBV. Itwas concluded that menin expressions could increase significantly in HBV-related HCC patients.
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