The Role of N-terminal Prohormone of Brain Natriuretic Peptide in the Severity of Coronary Artery Disease (Gensini Score) in Patients with Unstable Angina

摘要

Coronary artery disease (CAD) is one of the leading causes of mortality in industrialized and advanced countries. This cross-sectional study was aimed to determine the relationship between the severity of CAD (Gensini Score) and Nt-pro BNP in patients with unstable angina on the basis of analytical-descriptive and hospital-based information. The severity of coronary artery stenosis was calculated based on the Gensini Score criteria for coronary artery angiography. In this study, a positive angiographic group had at least one 70% stenosis in one of the LAD, LCX, RCA vessels, or at least 50% of the stenosis in the LM. To evaluate Nt-pro BNP, up to 24 hours after Chest pain began, a blood sample was taken from patients, and the amount of Nt-pro BNP was determined by ELISA and by electrochemical luminescence. We found NT-Pro BNPwere higher in female in compare to male patients. The mean NT-Pro BNP was signif icantly higher in angioplasty patients. According to the results of this study, serum NT-Pro BNP level revealed a direct correlation with the severity of coronary artery stenosis in the patients with U.S. and this marker can be used to differentiate patients who need more emergencytreatment.