Food protein-induced enterocolitis (FPIES), an entity previously thought to only affect children, has been increasingly described in adults. In this study, we report a Canadian cohort of 19 adolescents and adults with recurrent non-immunoglobulin E (IgE)-mediated gastrointestinal symptoms after crustacean ingestion, consistent with FPIES. We conducted a retrospective chart review of patients in an outpatient allergy clinic from January 2005 to May 2020. Electronic records were searched using keywords for crustaceans and for symptoms consistent with FPIES. We included patients with gastrointestinal symptoms specifically to crustaceans on more than one occasion, who were 14?years or older at the time of index reaction. Exclusion criteria included symptoms suggestive of an IgE-mediated anaphylactic reaction or a likely alternative diagnosis. We identified 19 patients for our cohort who met the criteria. Our cohort was 68.4% female (13) and 32.6% (6) male. The average age at first reaction to crustaceans was 34?years old with a range of 14–68?years (median?=?28?years; IQR?=?32?years). Time from ingestion to beginning of symptoms ranged from 3?min to 6.5?h, with an average of 2.8?h (median?=?2?h; IQR?=?3.25?h). Duration of reaction ranged from less than a minute to over 48?h, with a mean of 9.4?h (median?=?4?h; IQR?=?7.75?h). Patients had 4.8 reactions on average; however, number of reactions ranged from 2 to 12.5 (median?=?3, IQR?=?3). All patients identified a “trigger” food in the crustacean group, and 12 subjects identified additional reactions to other seafood. This case series will better characterize and advance our understanding of this disease entity in adults. There are key differences in the presentation of FPIES in adults compared to children, namely female predominance, difference in solid food trigger, and unpredictable time course. Future studies are needed to examine the pathophysiology and natural history of adult FPIES. Specific guidelines should be developed for the diagnosis and management in adults. Trial registration: retrospectively registered.
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