Introduction: Dermatophytosis is the most common fungal infections globally. Terbinafine is considered to have good potency against dermaphytes, but resistance to Terbinafine is on the rise. Objectives: The objective of this study was to do comparative study of Terbinafine in conventional dose versus double dose in treatment of Dermatophytosis. Methods: This cross-sectional comparison study conducted in the outpatient department of Cumilla Medical College Hospital, Cumilla, Bangladesh during the period from July 2018 to June 2019. In this randomized comparative study, patients of Tinea cruris and Tinea corporis were randomly divided into two groups of 87 each and were given oral Terbinafine in conventional dose (Group I) and oral Terbinafine in double dose (Group II) for 4 weeks. The scores and percentage changes measured from pruritus, scaling, and erythema were evaluated at 2~(nd) and 4~(th) weeks. Result: In total of 60 patients from both the groups completed the study. In this study it was found the Improvement rate of terbinafine double dose in higher 11.1 and 88.34 then the single dose. Conclusion: This study indicates that Terbinafine in a dose of 500 mg (double dose) given once daily was more effective than Terbinafine 250mg in the treatment of patients with Dermatophytosis.
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