The frequencies of antinuclear antibodies (ANA) have been associated with Systemic Lupus Erythematosus (SLE).In this study, we had evaluated the frequency of antinuclear antibodies associated with SLE by Line Immuno Assay (LIA).Clusters of antinuclear antibodies were identified using hierarchical clustering method.A total of 100 SLE patients (96 females, 4 males) with age ranging between 20 and 67 years were enrolled in this study.Five clusters of antibodies were identified in 100 SLE sera by cluster analysis.Cluster 1 contains antibodies to dsDNA, nucleosomes and histones; cluster 2 contains antibodies to CENP B, PCNA and Scl-70; cluster 3 contains antibodies to Jo-1, PM-Scl, SS-B, AMA-M2, Sm, Ribosomal P protein and SS-A; cluster 4 and 5 contain antibodies to Ro-52 and nRNP respectively.These results suggest that clusters of antinuclear antibodies were associated with SLE disease progression.
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