The administration of hydrophobic drugs by the oral route was presents a major challenge due to low water solubility drugs show their poor dissolution, which results in higher variability related to intra & inter subject and lack of dose congruence so solubility of orally administered drug a very task for the effective improvement and Introduce of newly launched medicines in the pharmaceutical industry.Self-emulsifying drug delivery systems (SEDDS) are isotropic mixtures of oils, surfactants/ solvents and co-solvents/co-surfactants and can be utilize to design such preparations which expand the oral absorption of more lipophilic drug molecules.Self-emulsification mechanism depends upon entropy change.The oral absorption efficiency of API molecules from the SEDDS, depends on various parameters which relates with formulation such as, concentration of surfactant, it’s ratio with oil phase, types of surfactant, and cosolvents, and viscosity enhancer.Present review provides an updated account of mechanism of self-emulsification of SEDDS with regard to its advantages, disadvantages, composition, solidification techniques to convert liquid SEDDS, evaluation.
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