Fragment-based drug discovery approaches have recently gained prominence as a distinct and complementary to drug discovery.Anticancer proteins present in the species such as Fennero penaeus indicus, Penaeus monodon, Litopenaeus vannamei and Metapenaeusensis were determined based on binding affinities against the cancer proteins causing human Lung, Blood, Pancreatic, Breast and Colon Cancer were identified and validated with protein-protein docking servers.The molecular conserved regions of the retrieved protein sequences are identified using T-COFFEE server and applied into CPH model server to predict the three dimensional structure of the target proteins.These studies were performed using advanced automated Protein – protein docking server called CLUSPRO.On comparing the docking values, the protein C Type Lectin of Fennero penaeus indicus shows higher binding affinity value is (-1282.5) and followed by Penaeus monodon (-1169.5) and Metapenaeus ensis (-1101.3) for lung cancer gene (CHRNA3).For the blood cancer gene (MLLT10), Metapenaeus ensis protein shows higher binding affinity value (-1010.3).Penaeus monodon binding affinity (-1013.4) with colon cancer (DCC), Based on the affinities we conclude that the proteins (CHRNA3) are best candidate Inhibitors (drug) for human cancers.
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