SOLUBILITY ENHANCEMENT OF LYCOPENE BY LYOPHILIZED POLYMERIC NANOPARTICLES

摘要

Lycopene is a potent anti-oxidant which has been widely reported for its potential benefits at reducing the risks of certain type of cancer.The oral bioavailability of this highly lipophilic carotenoid is low and highly influenced by the extent of intestinal lymphatic uptake.The aim of the study was to develop an optimized formulation which allows for efficient absorption following oral administration.Solid dispersion of lycopene were developed initially, subsequently a polymeric nanoparticles was designed by using PVP K 30 and Eudragit L 100 solvent evaporation method.This polymeric nanoparticles was solidify by the Lyophilization techniques.This polymeric nanoparticles was evaluated by zeta potential measurement, entrapment efficiency solubility studies and In-vitro drug release studies.So this study concluded that the solubility of polymeric nanoparticles (i.e.lyophilized powder) is greater than the solid dispersion of the same ratios.