We have made an attempt in the current study to synthesize eight novel indole derivatives (5a-h) and evaluate them for anti-inflammatory activity using Carrageenan-induced rat paw edema method.In the first step, we synthesized substituted acetophenone phenyl hydrozone(3a-h) by using phenyl hydrazine and substituted acetophenone in the presence of acetic acid and H2O.The substituted acetophenone phenyl hydrozone(3a-h) was further reacted with Vilsmeier-Hack reagent (POCl3–DMF) at 0-50C to afforded 2-(4- substituted)-1-H-indole-3-carbaldehyde (5a-h).The final indole derivatives (5a-h) were synthesized and recrystallized using ethanol.The structure of the final compound has been confirmed on the basis of FTIR and 1H NMR.All the values of FT-IR, 1H NMR, melting point, solubility and TLC were found to be prominent.The pharmacological screening by Carrageenan-induced rat paws edema method for antiinflammatiory activity revels that synthesized compounds 5a and 5f were found to be the most potent with compare to standard drugs Diclofenac sodium.
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