Purpose: A new sensitive sensor was fabricated for the determination of ivabradine hydrochloride (IH) based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase the sensitivity. Methods: The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic and differential pulse voltammetry. Results: The voltammetric response was linear over the range of 3.984 x 10-6-3.475 x 10-5 mol L-1. The limits of detection and quantification were found to be 5.160 x 10-7 and 1.720 x 10-6 mol L-1, respectively. Conclusion: This method is suitable for determination of IH in tablets and plasma.
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机译：目的：基于使用二烷基硫酸钠作为胶束介质的多丝碳纳米管的改性，制备了一种新的敏感传感器，用于测定Ivabradine盐酸盐（IH），以增加胶束介质以增加灵敏度。方法：使用循环和差分脉冲伏安法在Britton-Robinson缓冲液（pH：2.0-11.0）中研究IH的电化学行为。结果：伏安响应是线性的3.984 x 10-6-3.475 x 10-5 mol l-1。发现检测和定量的极限分别为5.160×10-7和1.720×10-6摩尔L-1。结论：该方法适用于片剂和血浆中的IH。
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