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外文期刊>Clinical and Experimental Gastroenterology
>The Impact of Virologic Parameters and Liver Fibrosis on Health-Related Quality of Life in Black African Patients with Chronic Hepatitis B: Results from a High Endemic Area
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The Impact of Virologic Parameters and Liver Fibrosis on Health-Related Quality of Life in Black African Patients with Chronic Hepatitis B: Results from a High Endemic Area
Background: The effects of virologic parameters, liver fibrosis, and treatment on the HRQoL in black African patients with CHB are unknown. Objective: To determine the magnitude and the effects of hepatitis B e antigen (HBeAg), hepatitis B surface antigenemia (HBs antigenemia), viral load, liver fibrosis and treatment on HRQoL impairment in black African patients with CHB using the SF36 (SF36) and chronic liver disease questionnaires (CLDQ). Materials and Methods: HRQoL comparison was determined in a case–control study and enrolled 214 patients with CHB (mean age: 42 years, male: 65.9%) and 210 healthy controls subjects (mean age: 37.8 years; male: 63.8%). Control subjects were younger than those with CHB (p=0.01). Analysis of covariance, Welch test and linear regression were used to compare HRQoL between subgroups. Results: Adjusted to age and gender, patients with CHB elicited low mean scores on the subscales of role-physical (66.9 vs 78, p=0.001), role-emotional (64 vs 77.5, p=0.01), bodily pain (70.8 vs 96.2, p=0.001), social functioning (74.6 vs 84.5, p=0.003) and general health (64.6 vs 74.4, p=0.03) in comparison with control subjects. Multivariate analysis showed that CHB impaired HRQoL on physical (β= ? 16.7 (1.8), p 0.0001) and mental component summaries (β= ? 5.1 (2.0), p=0.01) adjusted to others variables. Patients with HBeAg negative CHB elicited low scores on physical (p=0.004) and mental (p=0.05) component summaries and low CLDQ’s average score (p=0.002) in comparison with those positive. Patients with low (≤ 1000 IU/mL) HBs antigenemia (p=0.03) or viral load (p=0.03) scored less on physical component summary and those with significant fibrosis or cirrhosis scored less (p=0.003) on mental component summary. Conclusion: Black African patients with CHB expressed poor HRQoL, particularly those with HBeAg negative CHB, low viral load, or HBs Antigenemia.
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机译：背景：病毒学参数，肝纤维化和治疗对黑黑非洲CHB患者HRQOL的影响是未知的。目的：确定乙型肝炎抗原（HBEAG），乙型肝炎表面抗原血症（HBS抗原血症），病毒载荷，肝纤维化和治疗HRQOL损伤使用SF36（SF36）和患者HRQOL损伤治疗的幅度和效果慢性肝病问卷（CLDQ）。材料和方法：在病例对照研究中确定了HRQOL比较，并注册了214例CHB患者（平均年龄：42岁，男性：65.9％）和210个健康对照科目（平均年龄：37.8岁;男性：63.8％）。对照受试者比含ChB的细胞更小（P = 0.01）。使用协方差分析，韦尔奇试验和线性回归用于比较亚组之间的HRQOL。结果：调整年龄和性别，患者CHB引起上角色的物理的分量表低平均分数（66.9比78，P = 0.001），角色的情绪（64 VS 77.5，P = 0.01），身体疼痛（70.8 VS 96.2，P = 0.001），社交功能（74.6 Vs 84.5，P = 0.003）和一般健康（64.6 Vs 74.4，P = 0.03），与对照受试者相比。多变量分析表明，物理（β=α16.7（1.8），P <0.0001）和精神成分摘要（β=Δ5.1（2.0），P = 0.01）调整到其他变量，CHB受损。与那些阳性相比，HBEAG阴性CHB的患者在物理（P = 0.004）和精神上（P = 0.004）和精神（P = 0.05）组分摘要（P = 0.002）上引起低分。低（≤1000IU/ mL）HBS抗原血症（P = 0.03）或病毒载量（P = 0.03）在物理成分摘要上较少，纤维化或肝硬化的患者较少（P = 0.003）的精神组分摘要。结论：黑色非洲CHB患者表达贫困的HRQOL，尤其是HBEAG阴性CHB，低病毒载荷或HBS抗原血症的患者。
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