Identification of a novel miR‐21‐3p/TGF‐β signaling‐driven immune escape via the MHC class I/biglycan axis in tumor cells

摘要

For the first time, a miR-21-3p-mediated downregu- lation of MHC class I surface antigens was shown in different model systems, which is linked to the expression of the extracellular matrix (ECM) constituent biglycan (BGN) and transforming growth factor (TGF)-β signaling in HER-2/neu-positive (HER-2/neu + ) cells. HER-2/neu transformationinducestheexpressionofmiR-21-3p,which interferes with the expression of immune-modulatory molecules, thereby accelerating immune suppression and reducing tumor immunogenicity.