Abnormal lipoprotein metabolism is related to hyperlipidemia 1 and cardiovascular disease. 2 Here, abnormal proteins of three different density lipoproteins were identified in hyperlipidemic golden hamsters by label-free and targeted proteomics for the first time, including 13 new proteins. Functional analysis of differ- ential proteins provided new insights into the relationship between lipoprotein components and hyperlipidemia. Comparing with previous studies, 3–5 we achieve a better coverage and accuracy in lipoprotein proteins, providing a largest lipoprotein database to date.
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