A study of aerobic and anaerobic bacterial profile along with In vitro antibiotic susceptibility pattern in cases of puerperal, postabortion sepsis in a Tertiary Care Hospital

摘要

Background: Puerperal pyrexia and sepsis are still among the leading causes of preventable maternal morbidity and mortality both in developing and developed countries. The study was aimed to determine the causative organisms, risk factors, and antibiotic susceptibility of the isolates of puerperal sepsis. Materials and Methods: A total of 52 clinically suspected cases of puerperal sepsis were included in this study. Collected blood and endocervical samples were inoculated in appropriate culture media and incubated both aerobic and anaerobically. The isolated organisms were identified by standard biochemical tests. Antimicrobial sensitivity testing was performed by as per the CLSI guidelines. Results and Observation: In the present study, among 52 patients, majority of women (61.53%) were between 20 and 25 years and uniparous (55.76%). The present study showed predominance of Gram-negative bacilli (82.69%) with 17.30% isolates being Gram-positive cocci. Klebsiella pneumoniae (28.84%) was the most frequent isolate pathogen followed by Escherichia coli (19.23%). Bacteremia was present in 27.03% of cases. Most of the organisms were resistant to commonly used antibiotics such as amoxicillin, ciprofloxacin, levofloxacin, and amikacin. Conclusion: In the prospect of changing the spectrum of pathogens of puerperal sepsis and their antibiotic susceptibility patterns from time to time, positive blood culture and the antibiotic susceptibility testing of the isolates are the best guides in choosing the appropriate antimicrobial therapy in the treatment of puerperal sepsis.