Abstract Alzheimer's disease (AD) is the most common cause of cognitive impairment in the elderly. However, the pathogenesis of AD remains unclear. Persistent excessive inflammatory response plays a pivotal role in the development of AD. It has been suggested that activation of the nucleotide-binding oligomerization domain?like receptor protein 3 (NLRP3) inflammasome is important for inflammatory response in AD. This article reviews the structure and activation of NLRP3 inflammasome and the specific inhibitors of NLRP3 inflammasome.
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