Introduction: BCa is the second most common genitourinary malignancyafter prostate cancer. We set to examine the overall and stage-specificageadjusted incidence, five-year survival and mortality rates of BCa in theUnited States, between 1973 and 2006.Methods: We identified 136339 patients that were diagnosed with histologicallyconfirmed BCa between 1973 and 2006, within the Surveillance,Epidemiology and End Results database. Age-adjusted incidence, mortality,and five-year cancer-specific survival rates were calculated. Temporaltrends of age-adjusted incidence and mortality rates were quantified usingthe estimated annual percentage change (EAPC). All analyses were stratifiedaccording to disease stage.Results: Age-adjusted incidence rate of BCa increased from 21.0 to 25.8 per100 000 person-years between 1973 and 2006. For the same time period,stage-specific analyses revealed an increase for localized stage BCa: 15.4to 20.4 (EAPC: +0.7%, p0.001) and distant stage BCa: 0.5 to 0.7 (EAPC:+0.7%, p=0.003). No significant changes were observed for regional stage.Stage-specific five-year survival rates increased for all stages, except fordistant disease. No significant changes in mortality were recorded amonglocalized (EAPC: -0.2%, p=0.1) and regional stage (EAPC: -0.1%, p=0.2).However, an increase in mortality rates was observed among distant stage(EAPC: +0.6%, p=0.02).Conclusions: Virtually all changes in incidence, survival and mortality wereminor, and hardly of any clinical importance. Consequently, it appears thatfor all BCa stages. no improvement in detection or management has beenachieved during the last 30 years.
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