During the last decades, several studies have beenpublished and have led to the data collection on the acid?basedisorder and endothelial function (Celotto et al., 2008).It was determined that extracellular acidification induced byHCl (7.4 to 6.5) promotes NO, K (ATP) and SK-mediatedvasodilation (Ca), and perhaps other K (+) channels inthe isolated thoracic aorta of the rat (Celotto et al., 2011).The scientific literature has many reports on acid-basebalance and endothelium function, but these concepts areunclear about acid-base disorders and their relationship tothe three known mechanisms of endothelium-dependentvascular reactivity: nitric oxide (NO/cGMP-dependent),prostacyclin (PGI2/cAMP-dependent) and hyperpolarization.
展开▼
