The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of butorphanol were measured at predetermined time points using liquid chromatography/mass spectrometry assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butorphanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses.
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机译:本研究的目的是描述鼻内给予马匹后的丁啡醇药代动力学和生物利用度。六个成年马在随机交叉设计中接受了0.05 mg / kg丁啡醇,通过静脉内或鼻内路线。使用液相色谱/质谱法测定在预定时间点处测量丁啡磺醇的血浆浓度。静脉注射后,平均值±Sd丁甘醇稳态分布和间隙分别为3.20±1.77L / kg和3.18±1.47L / kg / kg / kg / h。静脉内和鼻内施用后丁啡醇的终端半衰期为0.68±0.17小时和1.79±1.43小时。对于鼻内给药,吸收半衰期和峰血浆浓度分别为0.43±0.33 h和1.95±1.7ng / ml。生物利用度为54.45±20.09%。在马匹中鼻内丁啡醇给药是实际的,不压力和耐受性良好。因此,它可能是成年马中的静脉内途径。
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