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Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation

机译:死亡肾移植后延迟移植物患者的预测因子和一年成果

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摘要

Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival. This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors. The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P??0.05). The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.
机译:由于移植过程中的缺陷和接受者,延迟移植函数(DGF)与使用边缘捐赠的肾脏密切相关。我们的目标是预测DGF的发病率并评估其对移植物存活的影响。这项回顾性研究肾移植研究于2018年1月1日至2019年12月31日,在中南大学第二届湘雅医院。我们分类了在不同年份在不同年份进行的收件人,进入培训和验证队伍和使用培训队员的数据来分析DGF的预测因子。然后构建一个基于这些预测因子的DGF的可能性。 DGF的发生率为16.92%。二元逻辑回归分析显示DGF和冷缺血时间(CIT),温暖缺血时间(机智),末端血清肌酸(SCR)浓度,预体透析持续时间,供体死亡的持续时间和Lifeport的使用情况之间的相关性。墨顶图的内部准确性为83.12%。一年的移植物存活率分别为93.59和99.74%,分别为具有和不含DGF的组(P?<?0.05)。本研究中建立的载体图表在死亡的供体肾移植后预测DGF的良好准确性;此外,DGF减少了一年的移植物存活。

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