Next-Generation Sequencing-driven analysis and SystemsBiology approaches commonly serve as a backdrop for astudy of a tumor genome. This issue of BMC Medical Genomics SBB-2019 (“Systems Biology and Bioinformatics”)presents recent works discussed at the 11th Young Scientists School “Systems Biology and Bioinformatics”-2019,held in Novosibirsk, Russia (http://conf.bionet.nsc.ru/sbb2019/en/). Here we collated some cancer gene expressionstudies, some mutation profiling studies as well as someinsightful case reports. The SBB school series on bioinformatics proceeds annually since 2008 under the joint steerage of the Institute of Cytology and Genetics of theSiberian Branch of the Russian Academy of Sciences andNovosibirsk State University [1, 2]. We had publications inspecial topic issues after the Schools before in BMC Genomics, BMC Medical Genomics and related BioMed Central family journals since 2014 [3–5]. The SBB Schools inNovosibirsk were initially conceived as satellite event foryoung scientists held at the same time as BGRSSB (Bioinformatics of Genome Regulation and Structure SystemsBiology) conference series, since 1998 taking place biannually. The recent BGRSSB-2020 event in Novosibirsk wasover at the time of the current journal issue publication(https://bgrssb.icgbio.ru/2020/). Other special issues (Supplements) to the BMC journals in the fields of genomics,genetics, bioinformatics, and medical genetics are publishedat BMC Genomics, BMC Genetics and three other BMCjournals. The BGRSSB-2018 conference highlights werepublished in 2018 [5–7], and continued the BMC MedicalGenomics special issues in 2019 [8]. Public discussion ofthe conference presentations at the open access platformsof BioMed Central and other publishers serve as an international educational resource for young scientists [9, 10].
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