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Estimation of Risk Factor's Contribution to mortality from COVID-19 in Highly Populated European Countries

机译:估计风险因素对高级欧洲国家的Covid-19对死亡率的贡献

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Background: The outbreak of the COVID-19 epidemic and the excess of mortality attributed to COVID-19 worldwide raised the need to develop a simple and applicable mathematical model for predicting mortality in different countries, as well as to point out the risk factors for COVID-19 mortality, and, in particular, demographic risk factors. Methods: A linear model was developed based on demographic data (population density, percentage of population over age 65 and degree of urbanity) as well as a clinical data (number of days since the first case was diagnosed in each country) from 10 highly populated (over 8.5 million people) randomly selected European countries (Austria, Hungary, Portugal, Sweden, Czech Republic, Belgium, the Netherlands, Romania, Italy, France). A linear regression model was applied, using IBM SPSS version 20 software. Results: The proposed model predicts mortality among the selected countries. This model is found to be highly correlated (R~2=0.821, p=0.042) with the actual (reported) number of deaths in each country. Percentage of population above age 65, population density and number of days since the first case appear at each state were found to be positively correlated with COVID-19 mortality, whereas urbanity were negatively correlated with mortality. Conclusions: Percentage of population above age 65 and population's density and the number of days of exposure to COVID 19 are potential risk factors for dying from the pandemic, whereas, urbanity is considered a protective factor. However, it should be remembered that this model is based on data from medium to large populations and only in continental Europe. Moreover, it is based on mortality data of the "first wave" of the pandemic. Further study should evaluate the model accuracy based on data from the "second wave" and not only in continental Europe.
机译:背景:Covid-19流行病的爆发以及归因于全球Covid-19的过度死亡率提出了为预测不同国家的死亡率的简单和适用的数学模型,以及指出Covid的风险因素-19死亡率,特别是人口危险因素。方法:基于人口统计数据(人口密度,65岁以上人口的百分比以及城市的人口的百分比)以及临床数据(自第一个案例诊断的天数),从10个普遍填充(超过850万人)随机选择欧洲国家(奥地利,匈牙利,葡萄牙,瑞典,捷克共和国,比利时,荷兰,罗马尼亚,意大利,法国)。应用了线性回归模型,使用IBM SPSS版本20软件。结果:拟议模型预测所选国家的死亡率。该模型被发现高度相关(R〜2 = 0.821,p = 0.042),其中每个国家的实际(报告)死亡人数。发现65岁以上人口的百分比,人口密度和自第一个案例出现在每个州以来的日子数量与Covid-19死亡率正相关,而城市与死亡率呈负相关。结论:65岁以上人口百分比和人口密度和接触Covid 19的天数是从大流行死亡的潜在危险因素,而城市则被认为是一种保护因素。但是,应该记住,该模型基于中等到大型人群的数据,只在大陆欧洲。此外,它基于大流行的“第一波”的死亡率数据。进一步的研究应根据“第二波”的数据来评估模型精度,不仅在大陆欧洲。

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