Highly efficient regio and diastereoselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties

摘要

A simple, efficient, regioselective and diastereoselective method has been developed for the synthesis of diversely functionalized spirooxindole-pyrrolidines using 0.5 mol% of ceric ammonium nitrate in aqueous medium. All the new compounds are tested for in vitro antimicrobial activity. All the synthesized products have shown good antimicrobial activity against Bacillus subtilis , Staphylococcus aureus , Micrococcus luteus (Gram-positive organisms), Salmonella paratyphi , Pseudomonas aeruginosa and Salmonella typhi (Gram-negative organism).