Pharma Biotech Congress 2018 Light-enabled drug delivery-Martin Michael Dcona-Virginia Commonwealth University

摘要

Conjugates are provided at, which comprise the membranepermeable drug linked to a moiety that is not membranepermeable. Attachment of moiety is not membrane permeableto prevents the drug from crossing cell membrane’s andentering in to the cells. However, to exposure the light either i)Break the linkage, releasing the drugandallowing it to cells; orii) Convert’s the non-membrane permeable moiety to amembrane permeable form, allowing the entire conjugate in toenter cell, where the drug is released from the conjugate by thecleavage. The membrane will permeable in to drugs are thusdelivered to cells at locations of interest, e.g. cancer cells in atumour, in a temporally and spatially controlled manner.